Plants detect microbial structures through pattern recognition receptors (PRRs), for instance receptor- like kinase proteins (RLKs) and receptor-like proteins (RLPs), which are transmembrane proteins with or without a cytoplasmic kinase domain for intracellular signal transduction and an extracellular domain responsible for ligand perception. Recently, we identified several Arabidopsis thaliana RLPs as immune receptors for peptide ligands and the RLK SOBIR1 as their adaptor kinase. RLP/SOBIR1 complexes thus possibly constitute bimolecular RLKs.
To address the question of commonalities and differences between LRR-RK and LRR-RP signaling, we conducted a survey of Arabidopsis thaliana immune signaling events mediated by these receptors.
- Until 2000 diploma studies and PhD at the University of Kaiserlautern (Germany): Diploma in the lab of Prof. Uwe Conrath on systemic acquired resistance in tobacco, PhD in the lab of Prof. Raimund Tenhaken on the hypersensitive response in soybean.
- 2000 until 2004 Postdoc in the lab of Prof. Jonathan Jones/Prof. Tina Romeis at the Sainsbury laboratory, Norwich, working on function of CDPKs and Receptor-like cytoplasmic kinases in Cf-9 signalling in tomato/tobacco.
- since 2004 senior scientist at the ZMBP/University of Tuebingen in the plant biochemistry department headed by Prof. Thorsten Nürnberger, working on identification of novel MAMPs and their corresponding receptors/co-receptors (LysM proteins - PGN; LRR-proteins - peptide ligands).