“A vibrant society and an ambitious nation must have a foundation of good health,” KAUST President Sir Edward Byrne AC told the inaugural KCSH Conference: Shaping the Future of Smart Health. Drawing on his long career in healthcare research, he emphasized the importance of harnessing AI, bioengineering, genomics, data science, and smart technology to deliver high-impact solutions for human health. In his expert opinion and experience, KAUST and its Center of Excellence for Smart Health are global leaders in this field.