The requirement of statistically robust microscopy data in order to publish in high level journals has drastically increased in the past few years. Based on this fact, with the support of the NCCR Chemical Biology and the University of Geneva, we build up ACCESS Geneva, a platform dedicated to the promotion of automated microscopy for all labs running confocal microscopy assay. This technology, which appeared in the early 2000th, has improved a lot in the past 5 years to reach the imaging quality of any stand-alone set-up. The serious advantages of the technology are numerous and at several levels: the quality and the consistency of imaging, the fast and unbiased image acquisition, the dramatic increase of sample size and by consequence the statistical strength of the quantifications.
In this presentation, I will explain how our platform is organized, how we analyze the data and handle them at the IT level and what is the amount of data we generate per year. I will present several examples of projects, that have benefited from the technology and explain why those projects would have been impossible without automated microscopy.
Undergraduate studies in La Rochelle west coast of France in Marine biology. Master at the National Museum of Natural History in Paris on Natural Bio-toxins. PhD at Faculty of Pharmacy of Nantes on Natural compound and lung cancer. Post-Doc in Singapore, IMCB, with Fred Bard, siRNA full genome screening on Ricin toxin and Pseudomonas exotoxins (investigation of retrograde transport). Post-Doc at University of Geneva with Jean Gruenberg, compound screening on cholesterol homeostasis and NPC rare disease. In 2016, I build up the ACCESS Geneva screening facility to make high throughput technologies an everyday tool for the Swiss academic and start up community