Abstract:
Electrochemical biosensors are attractive for point-of-care diagnostics as they can detect analytes with high sensitivity and provide a rapid response. They are also easy to miniaturize and can thus be portable. This talk focuses on the development of nanobody and antibody-immobilized electrodes for the detection of glial fibrillary acidic protein (GFAP), a promising biomarker for diagnostic and prognostic applications for brain trauma and dementia-like neurological disorders. This talk discusses the use of electrochemical impedance spectroscopy to probe the electrode surface and its binding interactions with GFAP using Hexaammineruthenium (III) chloride as the redox probe, with emphasis on how the redox probe and the impedimetric sensor operation affect the biorecognition-unit immobilized electrode stability and response to protein binding.

Bio:
Bayan is a Master’s student in Bioengineering under the supervision of Professor Sahika Inal. She completed her Bachelor’s in Biomedical Engineering from Milwaukee School of Engineering. Prior to starting her Master’s, she joined KAUST as a part of the Elevate training program. In her Master’s, she focused on the development and optimization of biosensors to provide reliable point-of-care diagnosis.