Abstract:
This talk explores the application of spatial transcriptomics (ST) to unravel key biological processes across different tissue types, including the heart, human growth plate, and bone marrow. Using a combination of bulk RNA-seq, scRNA-seq, and ST, we investigated the temporal and spatial dynamics of cardiac fibroblast (CF) differentiation during post-myocardial infarction repair. In the human growth plate, spatial profiling revealed novel markers and quiescent subpopulations of chondrocytes within the bone resting zone (bRZ), enhancing our understanding of bone development. Finally, in the context of multiple myeloma, ST uncovered spatial heterogeneity in the bone marrow microenvironment, highlighting immune suppression mechanisms near plasma cells. This comprehensive approach underscores the translational potential of spatial omics technologies for advancing our understanding of tissue-specific pathology and repair mechanisms.

Bio:
PhD candidate in Prof. Gomez-Cabrero lab.