Abstract:
This thesis explores strategies to improve CRISPR-Cas9-mediated homology-directed repair efficiency, mitigate large deletions caused by alternative repair pathways, and elucidate Wiskott-Aldrich syndrome protein (WASP)’s role in macrophage inflammatory responses. Together, these studies aim to advance genome editing for clinical applications and provide a framework for immune response regulation through targeted molecular interactions.

Bio:
I joined the Laboratory of Stem Cell and Regeneration as a PhD student under the supervision of Prof. Mo Li in 2020. My research focused on mechanisms of CRISPR genome editing and human disease-relevant genes.