Detecting metabolites at close range

22 June, 2018

​A novel concept for a biosensor of the metabolite known as lactate, combines an electron transporting polymer with lactate oxidase, which is the enzyme that specifically catalyzes the oxidation of lactate. Lactate is associated with critical medical conditions so its detection is important for healthcare.

Biosensor performance hinges on electron transfer between sensing electrode and enzyme: this increases when there is a decrease in the distance between enzyme active sites and the electrode surface. Redox enzymes have emerged as optimal components for biosensors because their ability to realize electron transfer complements their specificity in target binding and catalytic activity.

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Image: Sahika Inal's team is working on a biosensor design that will detect metabolites in different environments. Left-right: First author Anna-Maria Pappa, Ph.D. student David Ohayon and Prof. Sahika Inal.
© 2018 KAUST