Abstract:
Synthetic-directed evolution (SDE) presents an innovative approach in plant biotechnology, enabling precise genetic modifications to enhance desired traits. This research establishes SDE strategies aimed at improving herbicide tolerance and crop resilience. By leveraging synthetic evolution techniques such as in vivo base editing, Replicon-BE, and CRISPR/Cas9- mediated targeting, I facilitated trans-kingdom evolution and localized sequence diversification, achieving efficient trait enhancement in plants. The study highlights promising in planta applications, demonstrating effective trait engineering through iterative genomic modifications. The findings highlights SDE’s transformative potential in advancing crop resilience and food security by developing climate-resilient, high-performing plant varieties.

Bio:
I joined KAUST and the Laboratory for Genome Engineering and Synthetic Biology (GELAB) as a master’s student, where I specialized in genetic and biomolecular studies of plants, with a particular focus on genome engineering. Upon completing my master’s degree, I continued at KAUST and GELAB as a PhD candidate, where my research focused on leveraging genome engineering and synthetic evolution tools to engineer plant traits. My doctoral work centered on applying these advanced tools to address challenges in the agricultural sector and develop innovative solutions for sustainable crop resilience.